Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models.

  title={Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models.},
  author={Irina Popova and Anton E Malkov and Anton I. Ivanov and E Samokhina and Svetlana Buldakova and Olena Gubkina and Alexander Osypov and R S Muhammadiev and Tanya Zilberter and Maxim Molchanov and Svetlana I. Paskevich and Misha Zilberter and Yuri Zilberter},
  journal={Neurobiology of disease},
Metabolic intervention strategy of epilepsy treatment has been gaining broader attention due to accumulated evidence that hypometabolism, manifested in humans as reduced brain glucose consumption, is a principal factor in acquired epilepsy. Therefore, targeting deficient energy metabolism may be an effective approach for treating epilepsy. To confront this pathology we utilized pyruvate, which besides being an anaplerotic mitochondrial fuel possesses a unique set of neuroprotective properties… CONTINUE READING
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