Metabolic control of virulence genes in Brucella abortus: HutC coordinates virB expression and the histidine utilization pathway by direct binding to both promoters.

@article{Sieira2010MetabolicCO,
  title={Metabolic control of virulence genes in Brucella abortus: HutC coordinates virB expression and the histidine utilization pathway by direct binding to both promoters.},
  author={Rodrigo Sieira and Gast{\'o}n M. Arocena and Lucas Bukata and Diego J Comerci and Rodolfo Augusto Ugalde},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 1},
  pages={
          217-24
        }
}
Type IV secretion systems (T4SS) are multicomponent machineries involved in the translocation of effector molecules across the bacterial cell envelope. The virB operon of Brucella abortus codes for a T4SS that is essential for virulence and intracellular multiplication of the bacterium in the host. Previous studies showed that the virB operon of B. abortus is tightly regulated within the host cells. In order to identify factors implicated in the control of virB expression, we searched for… CONTINUE READING
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