Metabolic control of the epigenome in systemic Lupus erythematosus.

  title={Metabolic control of the epigenome in systemic Lupus erythematosus.},
  author={Zachary Oaks and Andr{\'a}s Perl},
  volume={47 4},
Epigenetic mechanisms are proposed to underlie aberrant gene expression in systemic lupus erythematosus (SLE) that results in dysregulation of the immune system and loss of tolerance. Modifications of DNA and histones require substrates derived from diet and intermediary metabolism. DNA and histone methyltransferases depend on S-adenosylmethionine (SAM) as a methyl donor. SAM is generated from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (MAT), a redox-sensitive… CONTINUE READING
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