Metabolic control of the circulation. Effects of acetate and pyruvate.

@article{Liang1978MetabolicCO,
  title={Metabolic control of the circulation. Effects of acetate and pyruvate.},
  author={Chang-seng Liang and John M. Lowenstein},
  journal={The Journal of clinical investigation},
  year={1978},
  volume={62 5},
  pages={1029-38}
}
Chloralose-anesthetized dogs were infused intravenously with either Tris-acetate or Tris-pyruvate at 0.0375, 0.075, and 0.15 mmol/kg per min successively, each for 20 min. Acetate infusion increased cardiac output, left ventricular dP/dt and dP/dt/P, and coronary blood flow, while pyruvate infusion did not. Infusions of either substance increased arterial blood and skeletal muscle concentrations of citrate and malate, but only acetate infusion increased the tissue AMP content and decreased the… CONTINUE READING

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