Metabolic control of puberty onset: New players, new mechanisms

  title={Metabolic control of puberty onset: New players, new mechanisms},
  author={Juan Roa and David Garc{\'i}a-Galiano and Juan Manuel Castellano and Francisco X Gayt{\'a}n and Leonor Pinilla and Manuel Tena-Sempere},
  journal={Molecular and Cellular Endocrinology},
Puberty, as the end-point of a complex series of maturational events affecting the components of the hypothalamic-pituitary-gonadal (HPG) axis, is gated by the state of body energy reserves and sensitive to different metabolic cues; conditions of severe metabolic stress and energy unbalance (from anorexia to morbid obesity) being commonly linked to perturbation of the onset of puberty. In the last two decades, the neuroendocrine mechanisms responsible for the tight coupling between energy… CONTINUE READING
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