Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

@article{Knobloch2012MetabolicCO,
  title={Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis},
  author={Marlen Knobloch and Simon M. G. Braun and Luis Zurkirchen and Carolin von Schoultz and Nicola Zamboni and Marcos Jes{\'u}s Ara{\'u}zo-Bravo and Werner J Kovacs and {\"O}zlem Karalay and Ueli Suter and Raquel Arminda Carvalho Machado and Marta Roccio and Matthias P Lutolf and Clay F Semenkovich and Sebastian Jessberger},
  journal={Nature},
  year={2012},
  volume={493},
  pages={226-230}
}
Mechanisms controlling the proliferative activity of neural stem and progenitor cells (NSPCs) have a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult NSPCs and that conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis. The rate of de novo lipid synthesis and subsequent… CONTINUE READING
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