Metabolic control during preimplantation mammalian development.

  title={Metabolic control during preimplantation mammalian development.},
  author={Henry J. Leese},
  journal={Human reproduction update},
  volume={1 1},
Metabolic control during preimplantation development may be either intrinsic to the embryo or extrinsic, i.e. mediated via the environment within the female tract. Intrinsic control is exhibited by early preimplantation embryos, which are undifferentiated, largely autonomous and show no growth. The best characterized intrinsic metabolic control mechanism is the switch from pyruvate to glucose as major energy substrate during mouse preimplantation development. A shift to extrinsic control occurs… CONTINUE READING