Metabolic control analysis using transient metabolite concentrations. Determination of metabolite concentration control coefficients.

@article{Delgado1992MetabolicCA,
  title={Metabolic control analysis using transient metabolite concentrations. Determination of metabolite concentration control coefficients.},
  author={Joaquin Delgado and James C. Liao},
  journal={The Biochemical journal},
  year={1992},
  volume={285 ( Pt 3)},
  pages={965-72}
}
The methodology previously developed for determining the Flux Control Coefficients [Delgado & Liao (1992) Biochem. J. 282, 919-927] is extended to the calculation of metabolite Concentration Control Coefficients. It is shown that the transient metabolite concentrations are related by a few algebraic equations, attributed to mass balance, stoichiometric constraints, quasi-equilibrium or quasi-steady states, and kinetic regulations. The coefficients in these relations can be estimated using… CONTINUE READING

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