Metabolic control analysis of moiety-conserved cycles.

  title={Metabolic control analysis of moiety-conserved cycles.},
  author={J. H. Hofmeyr and Henrik Kacser and Kirsten J van der Merwe},
  journal={European journal of biochemistry},
  volume={155 3},
Moiety-conserved cycles are metabolic structures that interconvert different forms of a chemical moiety (such as ATP-ADP-AMP, the different forms of adenylate), while the sum of these forms remains constant. Their metabolic behaviour is treated within the framework of control analysis [Kacser, H. & Burns, J.A. (1973) Symp. Soc. Exp. Biol 27, 65-104]. To explain the importance of the conserved sum of cycle metabolites as a parameter of the system, the cycle is first regarded as a 'black box… CONTINUE READING

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