Metabolic consequences of methylenecyclopropylglycine poisoning in rats.

@article{Melde1991MetabolicCO,
  title={Metabolic consequences of methylenecyclopropylglycine poisoning in rats.},
  author={K. Melde and S. Jackson and K. Bartlett and H. Sherratt and S. Ghisla},
  journal={The Biochemical journal},
  year={1991},
  volume={274 ( Pt 2)},
  pages={
          395-400
        }
}
We describe the effects of methylenecyclopropylglycine in fasted rats. A 75% decrease in the blood glucose concentration and an increase of lactate and pyruvate were observed 6 h after administration of 100 mg of this amino acid/kg. By contrast with the effects reported for hypoglycin [Williamson & Wilson (1965) Biochem. J. 94, 19c-21c], the plasma concentrations of ketone bodies decreased after administration of methylenecyclopropylglycine and the concentrations of branched-chain amino acids… Expand
Metabolism of levulinate and conversion to the drug of abuse 4-hydroxypentanoate
Redox control of beta-oxidation in rat liver mitochondria.
Quantification of hypoglycin A and methylenecyclopropylglycine in human plasma by HPLC-MS/MS.
Hereditary and acquired diseases of acyl-coenzyme A metabolism.
Control of mitochondrial beta-oxidation flux.
  • S. Eaton
  • Medicine, Biology
  • Progress in lipid research
  • 2002
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