Metabolic consequences of methotrexate therapy in tumour‐bearing rats

@article{Rofe1994MetabolicCO,
  title={Metabolic consequences of methotrexate therapy in tumour‐bearing rats},
  author={A. Rofe and C. S. Bourgeois and J. Washington and J. Philcox and P. Coyle},
  journal={Immunology and Cell Biology},
  year={1994},
  volume={72}
}
  • A. Rofe, C. S. Bourgeois, +2 authors P. Coyle
  • Published 1994
  • Medicine
  • Immunology and Cell Biology
  • The metabolic response of the tumour‐bearing host to methotrexate (MTX) therapy was investigated with particular attention to effects resulting from MTX‐induced anorexia. Biochemical changes in female Dark Agouti rats bearing mammary adenocarcinomas and treated with MTX (0.5 mg/kg. 2 i.m. injections, 24 h apart) were compared with untreated (CON) tumour‐bearing rats, and tumour‐bearing rats pair‐fed (PF) to the MTX group. MTX treatment halted progression of the tumour (tumour 6% of bodyweight… CONTINUE READING
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