Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and liver.

@article{Cusin1990MetabolicCO,
  title={Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and liver.},
  author={Isabelle Cusin and Johann Terrettaz and Françoise Rohner-Jeanrenaud and Bernard Jeanrenaud},
  journal={The Biochemical journal},
  year={1990},
  volume={267 1},
  pages={99-103}
}
The effects of hyperinsulinaemia imposed on normal rats on the subsequent insulin-responsiveness in vivo of 2-deoxy-D-glucose uptake of white adipose tissue and of various muscle types were investigated. This was done by treating normal rats with insulin via osmotic minipumps, and by comparing them with saline-infused controls. Hyperinsulinaemia produced by prior insulin treatment resulted in a well-tolerated hypoglycaemia. At the end of the treatment, the glucose utilization index of… CONTINUE READING
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