Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis
- Biology, MedicineRedox biology
Advances in understanding the impacts of global warming on marine fishes farmed offshore: Sparus aurata as a case study.
- Environmental ScienceJournal of fish biology
Understanding physiological responses to temperature fluctuations in fishes farmed offshore of open sea farmed can provide crucial background information for the conservation and successful management of aquaculture resources in the face of global change.
Functional validation of a human GLUD2 variant in a murine model of Parkinson’s disease
- BiologyCell death & disease
The results demonstrate that GLUD2 mutation in MPTP-induced PD mice exacerbates movement deficits and nigral dopaminergic neuron death and reduces glutamate transporters expression and function and unravel a mechanism by which a genetic variant in human GLud2 may contribute to disease onset.
Postnatal development of diving physiology: implications of anthropogenic disturbance for immature marine mammals
- Environmental ScienceJournal of Experimental Biology
The postnatal development of the body's oxygen stores, cardiorespiratory system and other attributes of diving physiology for pinnipeds and cetaceans are reviewed to assess how physiological immaturity makes young marine mammals vulnerable to disturbance.
A thermodynamic atlas of carbon redox chemical space
- ChemistryProceedings of the National Academy of Sciences
A systematic approach for comparing the chemical space of all possible redox states of linear-chain carbon molecules to the corresponding metabolites that appear in biology finds that aldose sugars have the highest possible number of redox connections to other molecules.
Venous hematology, biochemistry, and blood gas analysis of free-ranging Eastern Copperheads (Agkistrodon contortrix) and Eastern Ratsnakes (Pantherophis alleghaniensis)
- BiologyPloS one
This study provides guidelines for interpretation of venous hematology, plasma biochemistry, and blood gas values for free-ranging copperheads and ratsnakes in central North Carolina and demonstrates the physiological response to venous blood gas analytes secondary to capture and restraint.
Metabolic adaptations to anoxia and reoxygenation: New lessons from freshwater turtles and crucian carp
- Biology, Environmental Science
Extremely Elevated Myoglobin Contents in the Pelagic Melon-Headed Whale (Peponocephala electra) after Prolonged Postnatal Maturation
- Environmental Science, BiologyPhysiological and Biochemical Zoology
Unlike deep-diving and Arctic-dwelling odontocetes, melon-headed whales do not achieve mature muscle characteristics before nursing, and it is likely that early in life, the hydrodynamic benefits of swimming in echelon position with their mothers minimizes the endurance training of the calves that would otherwise promote rapid elevation in Mb.
The thermodynamic landscape of carbon redox biochemistry
Redox biochemistry plays a key role in the transduction of chemical energy in all living systems. Observed redox reactions in metabolic networks represent only a minuscule fraction of the space of…
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