Metabolic consequences of antiepileptic drugs.

  title={Metabolic consequences of antiepileptic drugs.},
  author={Scott E Mintzer},
  journal={Current opinion in neurology},
  volume={23 2},
PURPOSE OF REVIEW Chemical properties of the widely used older generation antiepileptic drugs (AEDs) suggest that they might be responsible for a number of medical comorbidities. RECENT FINDINGS AEDs which induce the cytochrome P450 system adversely affect bone, lipid, and gonadal steroid metabolism. Specifically, phenytoin causes loss of bone mass in women, and both phenytoin and carbamazepine produce increases in serum lipids and C-reactive protein, as well as decreases in bioactive… CONTINUE READING
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