Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration

@article{Karro2016MetabolicCI,
  title={Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration},
  author={Niina Karro and Mervi Sepp and Svetlana Jugai and Martin Laasmaa and Marko Vendelin and Rikke Birkedal},
  journal={Journal of Comparative Physiology B},
  year={2016},
  volume={187},
  pages={103-116}
}
  • Niina Karro, Mervi Sepp, +3 authors Rikke Birkedal
  • Published in
    Journal of Comparative…
    2016
  • Biology, Medicine
  • Rainbow trout (Oncorhynchus mykiss) cardiomyocytes have a simple morphology with fewer membrane structures such as sarcoplasmic reticulum and t-tubules penetrating the cytosol. Despite this, intracellular ADP diffusion is restricted. Intriguingly, although diffusion is restricted, trout cardiomyocytes seem to lack the coupling between mitochondrial creatine kinase (CK) and respiration. Our aim was to study the distribution of diffusion restrictions in permeabilized trout cardiomyocytes and… CONTINUE READING

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    Cardioprotective mitochondrial binding by hexokinase I is induced by a hyperoxic acute thermal insult in the rainbow trout (Oncorhynchus mykiss).

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