Metabolic clearance rate of aldosterone and the electrolyte and water metabolism in hepatic disorders

Abstract

The peculiar i t ies of re ta ining BSP were invest igated in hepatic diseases, especially for the purpose to s tudy the pathogenesis of const i tu t ional hyperbi l i rubinemia. Methods and Subjects: Total (T), free (F) and conjugated (C) BSP levels were examined by chromatography before and 15 minutes a f te r in t ravenous inject ion of dehydrocholic acid (DHC) of l g , which were performed immediately a f te r collecting a blood sample at 45 minutes in routine BSP test . The subjects included 16 l iver cirrhosis, 18 hepat i t is , 22 obstruct ive jaundice and 4 const i tut ional hyperbi l i rubinemia, diagnosed by biopsy, operat ion or autopsy. Results: a) In l iver cirrhosis, F-BSP decreased, but C-BSP showed li t t le changes af ter DHC injection. b) In hepat i t is , T-BSP and F-BSP showed no uni form changes. Elevat ion of C-BSP was observed in th ree cases with pers is tent hepat i t i s . c) In ex t rahepat ic obstruct ive jaundice, depression of F-BSP and elevat ion of C-BSP were observed af te r the injection. In in t rahepat ic obstruct ive jaundice, the changes in T-BSP, F-BSP and C-BSP were not uniform, but C-BSP/F-BSP rat io was h igher t h a n tha t in extrahepat ic . d) In const i tu t ional hyperbi l i rubinemia, Dubin-Johnson's syndrome showed s t r ik ing elevat ion of T-BSP, F-BSP and C-BSP af ter the inject ion. The elevation was more marked than spontaneous elevation observed character is t ical ly in this disease af ter rout ine BSP test . On the contrary in Rotor 's hyperbi l i rubinemia, T-BSP and F-BSP showed dis t inct depression af ter the injection.

DOI: 10.1007/BF02798204

Cite this paper

@article{Yoshitoshi2007MetabolicCR, title={Metabolic clearance rate of aldosterone and the electrolyte and water metabolism in hepatic disorders}, author={Yawara Yoshitoshi and Yuta Araki and Makoto Nagasaka and Osamu Yokota and Naokata Shimizu and Takeo Kato and Tamotsu Miyazaki and Hiroshi Mizukoshi and Toshiaki Kinouchi and Zhe Sai and Masato Kashima and Shoji Miura and K. Suzuki and M. Magoshi and Shinichi Ota and T. Ito}, journal={Gastroenterologia Japonica}, year={2007}, volume={1}, pages={54-55} }