Metabolic characterization of a L-lysine-producing strain by continuous culture.

  title={Metabolic characterization of a L-lysine-producing strain by continuous culture.},
  author={R D Kiss and Gregory Stephanopoulos},
  journal={Biotechnology and bioengineering},
  volume={39 5},
Continuous culture experiments with the L-producer, Corynebacterium glutamicum, were carried out to characterize the effect of specific growth rate on fermentation yields, specific rates, productivities, and fluxes through the primary metabolism. The specific productivity of L-lysine exhibited a maximum with respect to specific growth rate, with an initial growth-associated behavior up to specific growth rates of about 0.1 h(-1), and a constant specific productivity for specific growth rates in… CONTINUE READING
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