Metabolic characteristics of in vitro cultured human chondrocytes in relation to the histopathologic grade of osteoarthritis.

@article{Bulstra1989MetabolicCO,
  title={Metabolic characteristics of in vitro cultured human chondrocytes in relation to the histopathologic grade of osteoarthritis.},
  author={Sjoerd K. Bulstra and Wim A. Buurman and Gijs Walenkamp and Antje J van der Linden},
  journal={Clinical orthopaedics and related research},
  year={1989},
  volume={242},
  pages={
          294-302
        }
}
Isolated human chondrocytes derived from healthy and osteoarthritic (OA) cartilage were cultured in high density in a newly designed microculture system. The severity of OA was graded according to a modified histopathologic score originally described by Mankin et al. Chondrocytes from adult patients with OA showed 35S-sulphate and 3H-thymidine incorporation in vitro, which increased with severity of the disease through Mankin 11-12. Incorporation rapidly declined after Mankin 11-12. Both matrix… CONTINUE READING
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