Metabolic changes in the normal and hypoxic neonatal myocardium.

  title={Metabolic changes in the normal and hypoxic neonatal myocardium.},
  author={Salah Abdel-aleem and James D. St. Louis and Gillian Hughes and James E. Lowe},
  journal={Annals of the New York Academy of Sciences},
Hypoxia is characterized by inadequate oxygen delivery to the myocardium with a resulting imbalance between oxygen demand and energy supply. Several adaptive mechanisms occur to preserve myocardial survival during hypoxia. These include both short- and long-term mechanisms, which serve to achieve a new balance between myocardial oxygen demand and energy production. Short-term adaptation includes downregulation of myocardial function along with upregulation of energy production via anaerobic… CONTINUE READING

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