Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence.

@article{RodrguezContreras2006MetabolicCI,
  title={Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence.},
  author={Dayana Rodr{\'i}guez-Contreras and Scott M Landfear},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 29},
  pages={
          20068-76
        }
}

• Dayana Rodríguez-Contreras, Scott M Landfear
• Published in
  The Journal of biological…
  2006
• DOI:10.1074/jbc.M603265200

Leishmania mexicana are parasitic protozoa that express a variety of glycoconjugates that play important roles in their biology as well as the storage carbohydrate beta-mannan, which is an essential virulence factor for survival of intracellular amastigote forms in the mammalian host. Glucose transporter null mutants, which are viable as insect form promastigotes but not as amastigotes, do not take up glucose and other hexoses but are still able to synthesize these glycoconjugates and beta… CONTINUE READING

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