Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats

@article{Wu2015MetabolicCI,
  title={Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats},
  author={Yijen L. Wu and Patrice S. Pearce and Amedeo Rapuano and T. Kevin Hitchens and Nihal C. de Lanerolle and Jullie W Pan},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={2015},
  volume={35},
  pages={1862 - 1870}
}
There is little experimental in vivo data on how differences in seizure duration in experimental status epilepticus influence metabolic injury. This is of interest given that in humans, status duration is a factor that influences the probability of subsequent development of epilepsy. This question is studied using 7-T magnetic resonance (MR) spectroscopy, T2 relaxometry in the incremented kainate rodent model of temporal lobe epilepsy, using two durations of status epilepticus, 1.5 and 3 hours… 
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Methods Citations
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11 Citations

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Cognitive deficits and brain myo-Inositol are early biomarkers of epileptogenesis in a rat model of epilepsy
Metabolic injury in a variable rat model of post–status epilepticus
TLDR
A multivariate cluster analysis is taken to study a short duration status epilepticus model using in vivo 7T magnetic resonance spectroscopy and histologic evaluation to find discrete differences in injury after 40–50 min of seizures.
7T Magnetic Resonance Spectroscopy of Non-Lesional Temporal Lobe Epilepsy
TLDR
Results were in agreement with prior work in the literature showing non-lesional TLE is primarily a result of glial cell proliferation without neuronal atrophy, but in the patient cohort studied, these metabolites did not effectively lateralize seizure origin, potentially due to the varied underlying pathologies within the patient group.
Biomarkers of Epileptogenesis: The Focus on Glia and Cognitive Dysfunctions
TLDR
Evidence supporting the utility of measuring astrocyte activation, the soluble molecules they release, and the associated cognitive deficits during epileptogenesis for early stratification of animals developing epilepsy is reported.
Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy
TLDR
An overview of neuroimaging biomarkers in experimental epileptogenesis and refractory epilepsy is provided andidated biomarkers are warranted for early identification of people at risk for epilepsy and monitoring of the progression of medical interventions.
Neuroimaging in animal models of epilepsy
Brain magnetic resonance in status epilepticus: A focused review
Preliminary evaluation of accelerated microscopic diffusional kurtosis imaging (μDKI) in a rodent model of epilepsy.
Tipping the scales: Lessons from simple model systems on inositol imbalance in neurological disorders.
Organic washes of tissue sections for comprehensive analysis of small molecule metabolites by MALDI MS imaging of rat brain following status epilepticus
TLDR
An organic washes-based MALDI MSI was applied to the metabolic pathway analysis in rat brain following status epilepticus model, which was the first report about in-situ detection of a broad range of metabolites in the model of SE by MalDI MSI technique.
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References

SHOWING 1-10 OF 49 REFERENCES
In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium–pilocarpine-induced status epilepticus in the rat
A Novel, Noninvasive, Predictive Epilepsy Biomarker with Clinical Potential
TLDR
A novel MRI signature delineates the onset and suggests mechanisms of epileptogenesis that follow experimental FSE, and uses deoxyhemoglobin-sensitive MRI sequences to visualization of the predictive changes on lower-field, clinically relevant scanners.
Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study.
TLDR
Results are consistent with a reversible osmolyte reduction under hypoosmolar stress in the intact human brain and offer novel suggestions for treatment and monitoring of this common clinical event.
In vivo imaging of glia activation using 1H‐magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity
TLDR
The aim was to explore if glia activation during epileptogenesis, or in the chronic epileptic phase, can be used as a biomarker of tissue epileptogenicity (i.e., a measure of epilepsy severity) and to measure metabolite content in the rat hippocampus.
Brain Adaptation to Water Loading in Rabbits as Assessed by NMR Relaxometry
TLDR
It was shown that brain water content and T1 relaxation time remained unchanged despite the progressing hyponatremia and restructuring of brain water is a contributory factor to the successful adaptation to hypotonic environment.
Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy
TLDR
The most sensitive markers for developmental and regional variations between hippocampus, striatum, and cerebral cortex were N‐acetylaspartate, myo‐inositol, taurine, glutamate, and choline compounds, which may serve as a reference for studies focused on developmental defects and pathologies using neonatal rat models.
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy
Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: protection by antioxidants.
A Transient Upregulation of Glutamine Synthetase in the Dentate Gyrus Is Involved in Epileptogenesis Induced by Amygdala Kindling in the Rat
TLDR
Results strongly suggest that a transient and region-specific upregulation of GS function occurs when epilepsy develops into a certain stage and eventually promotes the process of epileptogenesis.
Latency to onset of status epilepticus determines molecular mechanisms of seizure-induced cell death.
...
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