Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway.

@article{Griffiths2002MetabolicCD,
  title={Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway.},
  author={John R. Griffiths and Paul M J McSheehy and Simon P Robinson and Helen Troy and Y L Chung and R. Leek and Kaye J. Williams and Ian James Stratford and Adrian L. Harris and Marion Stubbs},
  journal={Cancer research},
  year={2002},
  volume={62 3},
  pages={688-95}
}
Hypoxia-inducible factor-1 (HIF-1) regulates many pathways potentially important for tumor growth, including angiogenesis and glycolysis. Most attention has focused on its role in the response to hypoxia, but HIF-1 is also constitutively expressed in many tumors. To analyze the role of this pathway in vivo, we used magnetic resonance (MR) methods and complementary techniques to monitor metabolic changes in tumors derived from HEPA-1 mouse hepatoma lines that were either wild type (WT) or… CONTINUE READING

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