Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

@article{Payen2015MetabolicCA,
  title={Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway},
  author={Val{\'e}ry L. Payen and Paolo Ettore Porporato and Bjorn Baselet and Pierre Sonveaux},
  journal={Cellular and Molecular Life Sciences},
  year={2015},
  volume={73},
  pages={1333-1348}
}
Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are characterized by a high metabolic plasticity resulting from mutations and the selection of metabolic phenotypes conferring growth and invasive advantages. While metabolic plasticity allows cancer cells to cope with various microenvironmental situations that can be encountered in a primary tumor, there is increasing evidence that metabolism is also a major driver of cancer metastasis. Rather than a general… CONTINUE READING
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