Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.

@article{Edwards1975MetabolicCA,
  title={Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.},
  author={R. Timothy Edwards and D. K. Hill and D A Jones},
  journal={The Journal of physiology},
  year={1975},
  volume={251 2},
  pages={287-301}
}
1. The biochemical basis of the slowing of relaxation seen in fatigue has been examined using an isolated mouse soleus preparation. 2. Slowing of relaxation occurred during prolonged tetani under anaerobic conditions when ATP and PC fell and lactate accumulated. 3. Slowing of relaxation was also demonstrated with muscles poisoned with cyanide and iodoacetic acid when there was a fall in ATP and PC but no accumulation of lactate. During a period of anaerobic recovery following a fatiguing… CONTINUE READING

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