Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicity.

@article{Obrien1983MetabolicBO,
  title={Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicity.},
  author={Kevin O'brien and Eugene Moss and David J. Judah and Gregory Edward Neal},
  journal={Biochemical and biophysical research communications},
  year={1983},
  volume={114 2},
  pages={813-21}
}
Primary metabolism of aflatoxin B1 by the liver microsomal enzymes from a range of animal species showed both quantitative and qualitative differences. Quail was shown to have the most rapid metabolism of aflatoxin B1. The major product of metabolism in this case was found to be aflatoxin B1-8,9-dihydrodiol suggesting that the quail microsomes produced high levels of the proposed reactive intermediate aflatoxin B1-8,9-epoxide. Using this system to generate the epoxide, the ability of the… CONTINUE READING

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