Metabolic aspects of tacrolimus in renal transplantation. Consequences for the choice of an immunosuppressive regimen and for the management of post-transplant diabetes mellitus.

@article{Duijnhoven2003MetabolicAO,
  title={Metabolic aspects of tacrolimus in renal transplantation. Consequences for the choice of an immunosuppressive regimen and for the management of post-transplant diabetes mellitus.},
  author={Elly M. van Duijnhoven and Johannes M M Boots and Maarten H. L. Christiaans and Johannes P. van Hooff},
  journal={Minerva urologica e nefrologica = The Italian journal of urology and nephrology},
  year={2003},
  volume={55 1},
  pages={33-42}
}
The occurrence of post-transplant diabetes mellitus (PTDM) is an important complication after renal transplantation associated with an increased risk of chronic transplant dysfunction and of cardiovascular morbidity and mortality. Both tacrolimus and cyclosporine have been associated with PTDM. In the initial studies, PTDM seemed to occur more often in tacrolimus treated patients than in cyclosporine treated patients. The mechanism by which tacrolimus could cause PTDM was unknown and the… CONTINUE READING

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