Metabolic and respiratory effects of theophylline in the preterm infant

@article{Carnielli2000MetabolicAR,
  title={Metabolic and respiratory effects of theophylline in the preterm infant},
  author={Virgilio Paolo Carnielli and Giovanna Verlato and Franca Benini and K Rossi and M Cavedagni and Marco Filippone and Eugenio Baraldi and Franco Zacchello},
  journal={Archives of Disease in Childhood - Fetal and Neonatal Edition},
  year={2000},
  volume={83},
  pages={F39 - F43}
}
BACKGROUND Methylxanthines are often administered to preterm infants for the treatment of apnoea. AIMS To study the effects of theophylline on energy metabolism, physical activity, and lung mechanics in preterm infants. METHODS Indirect calorimetry was performed for six hours before and after administration of a bolus of theophylline (5 mg/kg) in 18 preterm infants while physical activity was recorded with a video camera. Lung mechanics measurements were performed at baseline and 12 and 24… Expand
Effects of theophylline on the pattern of spontaneous breathing in preterm infants less than 1000 g of birth weight.
TLDR
It is concluded that theophylline stimulates spontaneous breathing in infants less than 1000 g, reduces the number of apneas, and increases minute volume by increasing the tidal volumes. Expand
Comparison between Caffeine and Theophylline Therapy for Apnea of Prematurity
TLDR
Caffeine was as effective as theophylline in the short­term for reducing apnea in preterm babies and was better tolerated and was easier to administer. Expand
Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves.
TLDR
Doxapram had a more pronounced and faster effect on respiratory rate and elimination of CO(2) than theophylline, and is indicated for treatment of postnatal asphyxia in calves, but there are potential cardiovascular side effects. Expand
Caffeine therapy for apnea of prematurity.
TLDR
Caffeine therapy for apnea of prematurity reduces the rate of bronchopulmonary dysplasia in infants with very low birth weight and reduced weight gain temporarily. Expand
Effects of Postnatal Age and Aminophylline on the Maturation of Amplitude-Integrated Electroencephalography Activity in Preterm Infants
TLDR
The maturation of aEEG activity was found to be significantly correlated with postnatal age and with aminophylline use in clinically stable preterm infants, most notably with the degree of sleep-wake cycling as indicated by aEEg activity. Expand
Effects of Single Loading Dose of Intravenous Caffeine on Cerebral Oxygenation in Preterm Infants.
TLDR
A loading dose of caffeine temporarily reduces cerebral oxygenation and increases cerebral tissue oxygen extraction in preterm infants and most probably these changes reflect a physiological phenomenon without any clinical importance to the cerebral hemodynamics. Expand
Use of Methylxanthine Therapies for the Treatment and Prevention of Apnea of Prematurity
TLDR
This review of the literature on neonatal methylxanthine therapies found that caffeine is associated with fewer adverse effects and a wider therapeutic window when compared with theophylline, and larger doses of caffeine citrate have been shown to improve acute neonatal outcomes when administered promptly. Expand
Effect of Caffeine and Aminophylline on Apnea of Prematurity
TLDR
The obtained results revealed that there was no significant difference between the two groups in the therapeutic effect and side effects of caffeine and aminophylline in the treatment of idiopathic apnea of prematurity. Expand
Mechanistic actions of oxygen and methylxanthines on respiratory neural control and for the treatment of neonatal apnea
TLDR
AOP is chosen as one of the most common clinical scenarios involving apnea to highlight the mechanistic basis behind how some of the interventions could be both beneficial and also deleterious to the respiratory neural control system. Expand
Long-term neurodevelopment outcome of caffeine versus aminophylline therapy for apnea of prematurity.
TLDR
Caffeine and aminophylline showed similar effects in reducing the rate of mortality and improving the survival without neurodevelopment delays; though the clinical significance of caffeine over aminphylline cannot be undermined. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
Energy Expenditure, Lipolysis, and Glucose Production in Preterm Infants Treated with Theophylline
TLDR
It is speculated that theophylline treatment is not a major deterrent of weight gain in premature infants with lung disease, and therefore energy expenditure, body composition, lipolysis, glucose production, and gluconeogenesis from glycerol are not altered in preterm infants with apnea of prematurity treated therapeutically with theophyLLine. Expand
Oxygen consumption in apneic premature infants after low‐dose theophylline
TLDR
This dose of theophylline is effective in idiopathic apnea of prematurity and acts as a metabolic stimulant in the premature infant and increases in . Expand
Effect of aminophylline on respiratory center activity and metabolic rate in premature infants with idiopathic apnea.
TLDR
Findings support the hypothesis that apnea in premature infants is related to an immature respiratory center characterized by a decreased output, and Aminophylline probably increases respiratory center output by lowering the threshold of the central chemorecepter to CO2. Expand
Energy Balance, Physical Activity, and Thermogenic Effect of Feeding in Premature Infants
TLDR
The study suggests that the intradaily variation in energy expenditure in premature infants nursed according to present day techniques is almost equally due to the thermogenic effect of feeding and muscular activity, and to variations in muscular activity both representing a small fraction of the total energy expenditureIn premature infants. Expand
Physiologic changes induced by theophylline in the treatment of apnea in preterm infants.
TLDR
It is suggested that the decreased incidence of apnea after theophylline is associated with an increase in alveolar ventilation and increased sensitivity to CO2 with a pronounced shift of the CO2 response curve to the left. Expand
Aminophylline therapy for idiopathic apnea in premature infants: effects on lung function.
TLDR
The effectiveness of aminophylline in treating apnea in premature infants must be related to its central stimulating effect and not to an improvement in lung function and oxygenation. Expand
Theophylline affects sleep-wake state development in premature infants.
TLDR
It was concluded that theophylline altered the normal development of state organization in premature infants and these effects persisted long after the drug had cleared the body. Expand
Total parenteral nutrition in the newborn: impact of the quality of infused energy on nitrogen metabolism.
TLDR
It is suggested that for an intravenous energy intake ranging from 60 to 80 kcal.kg-1.d-1, glucose and fat provide an equivalent nitrogen sparing effect in the newborn infant. Expand
The Effect of Aminophylline on the Excursions of the Diaphragm in Preterm Neonates: A Randomized Double‐Blind Controlled Study
TLDR
It is indicated that aminophylline had a measurable effect on the diaphragmatic motion and further studies combining this technique with other techniques are needed to determine if the main effect of aminphylline in the prevention of apnoea is mainly central or peripheral. Expand
Effect of short-term fasting on the lipolytic response to theophylline.
TLDR
The results suggest that the inhibitory effect of adenosine on lipolysis is increased during short-term fasting. Expand
...
1
2
3
4
5
...