Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet

@article{Frassetto2009MetabolicAP,
  title={Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet},
  author={Lynda Ann Frassetto and Monique Schloetter and M Mietus-Synder and Robert C. Morris and Anthony Sebastian},
  journal={European Journal of Clinical Nutrition},
  year={2009},
  volume={63},
  pages={947-955}
}
Background:The contemporary American diet figures centrally in the pathogenesis of numerous chronic diseases—‘diseases of civilization’. We investigated in humans whether a diet similar to that consumed by our preagricultural hunter-gatherer ancestors (that is, a paleolithic type diet) confers health benefits.Methods:We performed an outpatient, metabolically controlled study, in nine nonobese sedentary healthy volunteers, ensuring no weight loss by daily weight. We compared the findings when… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Paleolithic vs. modern diets – slected pathophysiological implications
TLDR
This review addressed phytochemicals and cancer; calcium, physical exertion, bone mineral density and bone structural geometry; dietary protein, potassium, renal acid secretion and urinary calcium loss; and finally sarcopenia, adiposity, insulin receptors and insulin resistance. Expand
A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease
TLDR
A Palaeolithic diet may improve glucose tolerance independently of decreased waist circumference and the strong association between change in AUC Insulin0–120 and change in waist circumference did not remain after multivariate analysis. Expand
Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer.
TLDR
This review outlines the essence of the authors' hunter-gatherer genetic legacy and suggests practical steps to re-align their modern milieu with their ancient genome in an effort to improve cardiovascular health. Expand
Effects of a short-term intervention with a paleolithic diet in healthy volunteers
TLDR
This short-term intervention showed some favourable effects by the paleolithic diet, but further studies, including control group, are needed. Expand
Biological and Clinical Potential of a Palaeolithic Diet
TLDR
Increasing evidence suggests that a Palaeolithic diet based on lean meat, fish, vegetables and fruit may be effective in the prevention and treatment of common Western diseases. Expand
Origins and evolution of the Western diet: health implications for the 21st century.
TLDR
The evolutionary collision of the authors' ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization. Expand
Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial.
TLDR
In the setting of a healthful diet, partial substitution of carbohydrate with either protein or monounsaturated fat can further lower blood pressure, improve lipid levels, and reduce estimated cardiovascular risk. Expand
Dietary, total body, and intracellular potassium-to-sodium ratios and their influence on cancer.
  • B. Jansson
  • Biology, Medicine
  • Cancer detection and prevention
  • 1990
TLDR
The influence of the K/Na ratio on cancer development--first discovered by epidemiologic studies--has been confirmed by various means, such as dietary studies, gerontological studies, studies of relationships between hyper- and hypokalemic diseases and cancer, and review of the cellular changes of this ratio induced by carcinogenic and anticarcinogenic agents. Expand
Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet
TLDR
The effect of different levels of dietary sodium, in conjunction with the Dietary Approaches to Stop Hypertension (DASH) diet, which is rich in vegetables, fruits, and low-fat dairy products, in persons with and in those without hypertension is studied. Expand
Stone Agers in the Fast Lane: Chronic Degenerative Diseases in Evolutionary Perspective
TLDR
There is increasing evidence that the resulting mismatch fosters “diseases of civilization” that together cause 75 percent of ail deaths in Western nations, but that are rare among persons whose iifeways reflect those of the authors' preagricuiturai ancestors. Expand
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