Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation.

@article{Zhan1997MetabolicAP,
  title={Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation.},
  author={W Z Zhan and Hirofumi Miyata and Y. K. Subrahmanya Prakash and Gary C. Sieck},
  journal={Journal of applied physiology},
  year={1997},
  volume={82 4},
  pages={1145-53}
}
We hypothesized that metabolic adaptations to muscle inactivity are most pronounced when neurotrophic influence is disrupted. In rat diaphragm muscle (Dia(m)), 2 wk of unilateral denervation or tetrodotoxin nerve blockade resulted in a reduction in succinate dehydrogenase (SDH) activity of type I, IIa, and IIx fibers (approximately 50, 70, and 24%, respectively) and a decrease in SDH variability among fibers (approximately 63%). In contrast, inactivity induced by spinal cord hemisection at C2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…