• Medicine
  • Published in
    European journal of clinical…
    1992

Metabolic and neuroendocrine effects of pro-inflammatory cytokines.

@article{Rey1992MetabolicAN,
  title={Metabolic and neuroendocrine effects of pro-inflammatory cytokines.},
  author={Adriana del Rey and Hugo Oscar Besedovsky},
  journal={European journal of clinical investigation},
  year={1992},
  volume={22 Suppl 1},
  pages={
          10-5
        }
}
Immune-neuroendocrine interactions occur during physiological and pathological situations. Pro-inflammatory cytokines such as IL-1, IL-6 and TNF alpha play a role in mediating these interactions. Although all three cytokines can stimulate ACTH and glucocorticoid output, IL-1 has the highest potency. It is known that increased glucocorticoid levels result in hyperglycemia. However, administration of low doses of lipopolysaccharide (LPS), an inducer of several cytokines including those mentioned… CONTINUE READING

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