Corpus ID: 8423446

Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.

@article{Costantino2009MetabolicAH,
  title={Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.},
  author={Demetrio Costantino and G. Minozzi and E Minozzi and Claudia Guaraldi},
  journal={European review for medical and pharmacological sciences},
  year={2009},
  volume={13 2},
  pages={
          105-10
        }
}
To investigate the effects of treatment with Myo-inositol (an insulin sensitizing drug), on circulating insulin, glucose tolerance, ovulation and serum androgens concentrations in women with the Polycystic Ovary Syndrome (PCOS). [...] Key Method Forty-two women with PCOS were treated in a double-blind trial with Myo-inositol plus folic acid or folic acid alone as placebo. In the group treated with Myo-inositol the serum total testosterone decreased from 99.5 +/- 7 to 34.8 +/- 4.3 ng/dl (placebo group: from 116…Expand
Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome (PCOS).
TLDR
Combination of MI and DCI in a ratio 10:1 seems to be efficient in improving both metabolic and hormonal parameters in patients with PCOS. Expand
Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS)
TLDR
The two insulin-sensitizers, metformin and myo-inositol, show to be useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle without significant differences between the two treatments. Expand
Management of women with PCOS using myo-inositol and folic acid. New clinical data and review of the literature
TLDR
Myo-inositol has proven to be a new treatment option for patients with PCOS and infertility and the achieved pregnancy rates are at least in an equivalent or even superior range than those reported using metformin as an insulin sensitizer. Expand
Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial.
TLDR
It is suggested that myoinositol may be useful in the treatment of PCOS patients undergoing ovulation induction, both for its insulin-sensitizing activity, and its role in oocyte maturation. Expand
A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women
TLDR
The combined therapy of MI plus DCI is effective in improving endocrine and metabolic parameters in young obese PCOS affected women. Expand
Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials
TLDR
The trial sequential analysis of insulin meta-analysis illustrates that the cumulative z-curve crossed the monitoring boundary, providing firm evidence of the intervention effect of MI in improving the metabolic profile of women with PCOS, concomitantly reducing their hyperandrogenism. Expand
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials
TLDR
An overview on the clinical outcomes of the MYO use as a treatment to improve ovarian function and metabolic and hormonal parameters in women with PCOS is provided. Expand
Myo-Inositol in the Treatment of Teenagers Affected by PCOS
TLDR
Administration of MI is a safe and effective method to prevent and correct metabolic disorders in teenagers affected by PCOS and with combination of MI and OCPs antiandrogenic effects are enhanced, negative impact of O CPs on weight gain is balanced, and metabolic profile is improved. Expand
Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance
TLDR
Myo-inositol treatment ameliorates insulin resistance and body weight, and improves ovarian activity in PCOS patients, and reduces body mass index and HOMA index. Expand
Comparison between effects of myo-inositol and d-chiro-inositol on ovarian function and metabolic factors in women with PCOS
  • A. Pizzo, A. S. Laganà, L. Barbaro
  • Biology, Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2014
TLDR
Both the isoforms of inositol were effective in improving ovarian function and metabolism in patients with PCOS, although myo-Inositol showed the most marked effect on the metabolic profile, whereas d-chiro-inositol reduced hyperandrogenism better. Expand
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References

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Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.
  • M. J. Iuorno, D. Jakubowicz, +4 authors J. Nestler
  • Medicine
  • Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
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TLDR
It is concluded that, in lean women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities ( increased blood pressure and hypertriglyceridemia) of syndrome X. Expand
Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome
TLDR
It is hypothesized that the administration of d-chiro-inositol would replenish stores of the mediator and improve insulin sensitivity in 44 obese women with the polycystic ovary syndrome. Expand
Myo-inositol in patients with polycystic ovary syndrome: A novel method for ovulation induction
  • E. Papaleo, V. Unfer, +7 authors A. Ferrari
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2007
TLDR
Myo-inositol is a simple and safe treatment that is capable of restoring spontaneous ovarian activity and consequently fertility in most patients with PCOS, and did not cause multiple pregnancy. Expand
Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens.
TLDR
It is suggested that hyperinsulinemia stimulates ovarian P450c17 alpha activity in nonobese women with PCOS and decreasing serum insulin with metformin reduces ovarian cytochrome P 450c17alpha activity and ameliorates the hyperandrogenism of these women. Expand
Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
TLDR
Myo-inositol administration improves reproductive axis functioning in PCOS patients reducing the hyperinsulinemic state that affects LH secretion and insulin sensitivity, expressed as glucose-to-insulin ratio and HOMA index. Expand
Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.
TLDR
Data support a beneficial effect of myo-inositol in women with oligomenorrhea and polycystic ovaries in improving ovarian function and there was an inverse relationship between body mass and treatment efficacy. Expand
Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome.
TLDR
UCl(DCI) is inversely correlated with insulin sensitivity in women and is a strong independent predictor of insulin resistance in multivariate models, consistent with a defect in tissue availability or utilization of DCI in PCOS that may contribute to the insulin resistance of the syndrome. Expand
Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism.
TLDR
Greek women, with or without PCOS, display increased uCl (DCI) and decreased AUC(DCI-IPG) in association with higher insulin levels but independent of adiposity, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women. Expand
Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
TLDR
It is concluded that women with PCOS should periodically have an OGTT and must be closely monitored for deterioration in glucose tolerance, particularly among those with IGT, the subgroup at highest risk for subsequent development of NIDDM. Expand
Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality.
TLDR
It is proposed that higher concentrations of MI and E(2) in human FF appear to play a role in follicular maturity and provide a marker of good quality oocytes. Expand
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