Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease.

@article{Bril2017MetabolicAH,
  title={Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease.},
  author={Fernando Bril and Diana Barb and Paola Portillo-Sanchez and Diane Biernacki and Romina Lomonaco and Amitabh Suman and Michelle H. Weber and Jeffrey T Budd and Maria Elisa Lupi and Kenneth Cusi},
  journal={Hepatology},
  year={2017},
  volume={65 4},
  pages={1132-1144}
}
The cut-off point of intrahepatic triglyceride (IHTG) content to define nonalcoholic fatty liver disease (NAFLD) by proton magnetic resonance spectroscopy (1 H-MRS) was established based on the 95th percentile in a group of healthy individuals (i.e., ≥5.56%). Whether this threshold correlates with metabolic and histological changes and whether a further accumulation of IHTG is associated with worsening of these parameters has not been properly assessed in a large cohort of patients. In this… CONTINUE READING
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