Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.

@article{Stromski1988MetabolicAF,
  title={Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.},
  author={M E Stromski and A van Waarde and Malcolm J. Avison and Gunilla Thulin and Karen M. Gaudio and Michael Kashgarian and Robert G. Shulman and Norman J. Siegel},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={82 5},
  pages={
          1694-9
        }
}
The concentrations of renal ATP have been measured by 31P-nuclear magnetic resonance (NMR) before, during, and after bilateral renal artery occlusion. Using in vivo NMR, the initial postischemic recovery of ATP increased with the magnitude of the residual nucleotide pool at the end of ischemia. ATP levels after 120 min of reflow correlated with functional recovery at 24 h. In the present study the effect of blocking the degradation of ATP during ischemia upon the postischemic restoration of ATP… CONTINUE READING

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