Metabolic and endocrine response to exercise: sympathoadrenal integration with skeletal muscle.

@article{Ball2015MetabolicAE,
  title={Metabolic and endocrine response to exercise: sympathoadrenal integration with skeletal muscle.},
  author={Derek Ball},
  journal={The Journal of endocrinology},
  year={2015},
  volume={224 2},
  pages={
          R79-95
        }
}
  • D. Ball
  • Published 1 February 2015
  • Biology
  • The Journal of endocrinology
Skeletal muscle has the capacity to increase energy turnover by ∼1000 times its resting rate when contracting at the maximum force/power output. Since ATP is not stored in any appreciable quantity, the muscle requires a coordinated metabolic response to maintain an adequate supply of ATP to sustain contractile activity. The integration of intracellular metabolic pathways is dependent upon the cross-bridge cycling rate of myosin and actin, substrate availability and the accumulation of metabolic… 

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References

SHOWING 1-10 OF 220 REFERENCES
Hepatic fuel metabolism during muscular work: role and regulation.
TLDR
There is no evidence that hepatic innervation is essential for the rise in hepatic glucose production during exercise, but nonesterified fatty acid (NEFA) delivery to, uptake of, and oxidation by the liver are accelerated during prolonged exercise, resulting in an increase in ketogenesis.
Role of myokines in exercise and metabolism.
TLDR
The present review focuses on muscle-derived cytokines, their regulation by exercise, and their possible roles in metabolism and skeletal muscle function and it discusses which cytokines should be classified as true myokines.
Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise.
TLDR
It would appear that in humans acetyl group availability is a major determinant of the rate of increase in mitochondrial respiration at the onset of exercise and hence the oxygen deficit.
New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle
TLDR
The demonstration that carnitine availability can be readily manipulated in humans, and impacts on physiological function, will result in renewed business and scientific interest in this compound.
Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration.
TLDR
It is concluded that, whereas carbohydrate availability is regulated directly in relation to exercise intensity, the regulation of lipid metabolism seems to be more complex.
ATP production and efficiency of human skeletal muscle during intense exercise: effect of previous exercise.
TLDR
The present data suggest that the rate of ATP turnover increases during intense exercise at a constant work rate, and mechanical efficiency declines as intense exercise is continued.
Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans
TLDR
The data demonstrate that elevated plasma adrenaline levels during moderate exercise in untrained men increase skeletal muscle glycogen breakdown and PDH activation, which results in greater carbohydrate oxidation.
Interleukin-6 in acute exercise and training: what is the biological relevance?
TLDR
Extended exercise involving a significant muscle mass in the contractile activity is necessary in order to produce a marked systemic IL-6 response, and exercise training may reduce basalIL-6 production as well as the magnitude of the acute exercise IL- 6 response by counteracting several potential stimuli of IL-8.
Regulation of hepatic glucose production during exercise in humans: role of sympathoadrenergic activity.
TLDR
It is concluded that high physiological concentrations of Epi can enhance Ra in exercising humans, but normally Epi is not a major stimulus, and neither sympathetic liver nerve activity is a major stimuli for Ra during exercise.
Exercise, GLUT4, and skeletal muscle glucose uptake.
TLDR
Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease.
...
...