Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation.

@article{Granneman2005MetabolicAC,
  title={Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation.},
  author={James Gerard Granneman and Pipeng Li and Zhengxian Zhu and Yuyan Lu},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={289 4},
  pages={
          E608-16
        }
}
Selective agonists of beta(3)-adrenergic receptors (Adrb3) exhibit potent anti-diabetes properties in rodent models when given chronically, yet the mechanisms involved are poorly understood. A salient feature of chronic Adrb3 activation is pronounced remodeling of white adipose tissue (WAT), which includes mitochondrial biogenesis and elevation of metabolic rate. To gain insights into potential mechanisms underlying WAT remodeling, the time course of remodeling induced by the Adrb3 agonist CL… CONTINUE READING

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