Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances

@article{Kervezee2018MetabolicAC,
  title={Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances},
  author={Laura Kervezee and Anastasi Kosmadopoulos and Diane B. Boivin},
  journal={European Journal of Neuroscience},
  year={2018},
  volume={51},
  pages={396 - 412}
}
Shift work, defined as work occurring outside typical daytime working hours, is associated with an increased risk of various non‐communicable diseases, including diabetes and cardiovascular disease. Disruption of the internal circadian timing system and concomitant sleep disturbances is thought to play a critical role in the development of these health problems. Indeed, controlled laboratory studies have shown that short‐term circadian misalignment and sleep restriction independently impair… 
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Observing differential effects by genetic disposition after a one-hour advance underscores the importance of heterogeneity in adaptation to external schedule shifts, and these genetic differences may affect how individuals adjust to jet lag or shift work as well.
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