Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments.

@article{Mourad2010MetabolicAP,
  title={Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments.},
  author={Nizar I Mourad and Myriam Nenquin and J. -C. Henquin},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={299 2},
  pages={C389-98}
}
Two pathways control glucose-induced insulin secretion (IS) by beta-cells. The triggering pathway involves ATP-sensitive potassium (K(ATP)) channel-dependent depolarization, Ca(2+) influx, and a rise in the cytosolic Ca(2+) concentration ([Ca(2+)](c)), which triggers exocytosis of insulin granules. The metabolic amplifying pathway augments IS without further increasing [Ca(2+)](c). The underlying mechanisms are unknown. Here, we tested the hypothesis that amplification implicates actin… CONTINUE READING

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Newcomer insulin secretory granules as a highly calcium-sensitive pool.

Proceedings of the National Academy of Sciences of the United States of America • 2009
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