Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.

@article{Chaudhri2013MetabolicAI,
  title={Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.},
  author={Virendra K. Chaudhri and Gregory G. Salzler and Salihah A Dick and Melanie S. Buckman and Raffaella Sordella and Edward D. Karoly and Robert P. Mohney and Brendon M. Stiles and Olivier Elemento and Nasser Khaled Altorki and Timothy E McGraw},
  journal={Molecular cancer research : MCR},
  year={2013},
  volume={11 6},
  pages={579-92}
}
Cancer cells undergo a metabolic reprogramming but little is known about metabolic alterations of other cells within tumors. We use mass spectrometry-based profiling and a metabolic pathway-based systems analysis to compare 21 primary human lung cancer-associated fibroblast lines (CAF) to "normal" fibroblast lines (NF) generated from adjacent nonneoplastic lung tissue. CAFs are protumorigenic, although the mechanisms by which CAFs support tumors have not been elucidated. We have identified… CONTINUE READING

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