Metabolic age modelling: the lesson from centenarians.

  title={Metabolic age modelling: the lesson from centenarians.},
  author={Guiseppe Paolisso and Michelangela Barbieri and Massimiliano Bonaf{\'e} and Claudio Franceschi},
  journal={European journal of clinical investigation},
  volume={30 10},
Evolutionary theories of ageing, and data emerging from cellular and molecular biology of ageing, suggested that animals and humans capable of reaching an age close to the extreme limit of the life span should be equipped with a very efficient network of anti-ageing mechanisms. Indeed several evidences have demonstrated that starting from young to very old subjects, ageing is associated with a progressive remodelling. Thus, a new paradigm, the remodelling theory of age, was proposed. This… CONTINUE READING