Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents.

@article{Perrone2013MetabolicAT,
  title={Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents.},
  author={Carmen E. Perrone and Virginia L Malloy and David S. Orentreich and Norman Orentreich},
  journal={Experimental gerontology},
  year={2013},
  volume={48 7},
  pages={654-60}
}
Restriction of dietary methionine by 80% slows the progression of aged-related diseases and prolongs lifespan in rodents. A salient feature of the methionine restriction phenotype is the significant reduction of adipose tissue mass, which is associated with improvement of insulin sensitivity. These beneficial effects of MR involve a host of metabolic adaptations leading to increased mitochondrial biogenesis and function, elevated energy expenditure, changes of lipid and carbohydrate homeostasis… CONTINUE READING