Metabolic adaptations in rat hepatomas. II. Tryptophan pyrrolase and tyrosine alpha-ketoglutarate transaminase.


The administration of t ryptophan or cortisone to rats bearing the Morris 5123 Hepatoma resulted in significant increases in t ryptophan pyrrolase activity in the host liver but in no change in the low tryptophan pyrrolase activity of the neoplasm. The repressed level of this enzyme in the neoplasm was not a result of the lack or excess of cofactors or… (More)


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