Metabolic adaptation to reduced muscle blood flow. II. Mechanisms and beneficial effects.


Increased mitochondrial enzyme activities are induced in rat muscles after common iliac artery ligation, giving a 76-93% blood flow reduction, and 6 days of intermittent muscle stimulation. To elucidate the trigger for this enzyme induction, the acute alterations in the metabolite pattern during contractions were evaluated. More pronounced changes in… (More)


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