Metabolic adaptation during a sequence of no-flow and low-flow ischemia. A possible trigger for hibernation.

@article{Ferrari1996MetabolicAD,
  title={Metabolic adaptation during a sequence of no-flow and low-flow ischemia. A possible trigger for hibernation.},
  author={Roberto Ferrari and Anna Cargnoni and Palmira Bernocchi and Evasio Pasini and Salvatore Curello and Claudio Ceconi and Tom J. C. Ruigrok},
  journal={Circulation},
  year={1996},
  volume={94 10},
  pages={2587-96}
}
BACKGROUND Myocardial hibernation is an adaptive phenomenon occurring in patients with a history of acute ischemia followed by prolonged hypoperfusion. METHODS AND RESULTS We investigated, in isolated rabbit heart, whether a brief episode of global ischemia followed by hypoperfusion maintains viability. Four groups were studied; group 1,300 minutes of aerobia; group 2,240 minutes of total ischemia and 60 minutes of reperfusion; group 3, 10 minutes of total ischemia, 230 minutes of… CONTINUE READING