Metabolic adaptation after whole genome duplication.

  title={Metabolic adaptation after whole genome duplication.},
  author={Milan J A van Hoek and Paulien Hogeweg},
  journal={Molecular biology and evolution},
  volume={26 11},
Whole genome duplications (WGDs) have been hypothesized to be responsible for major transitions in evolution. However, the effects of WGD and subsequent gene loss on cellular behavior and metabolism are still poorly understood. Here we develop a genome scale evolutionary model to study the dynamics of gene loss and metabolic adaptation after WGD. Using the metabolic network of Saccharomyces cerevisiae as an example, we primarily study the outcome of WGD on yeast as it currently is. However… CONTINUE READING

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