Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.

@article{Chandor2008MetabolicAO,
  title={Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.},
  author={Alexia Chandor and Sylvie Dijols and Booma Ramassamy and Yves Michel Frapart and Daniel Mansuy and Dennis J Stuehr and Nuala Ann Helsby and Jean-Luc Boucher},
  journal={Chemical research in toxicology},
  year={2008},
  volume={21 4},
  pages={
          836-43
        }
}
Nitric oxide synthases (NOSs) are flavohemeproteins that catalyze the oxidation of L-arginine to L-citrulline with formation of the signaling molecule nitric oxide (NO). In addition to their fundamental role in NO biosynthesis, NOSs are also involved in the formation of reactive oxygen and nitrogen species (RONS) and in the interactions with some drugs. 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) is a dinitroaromatic compound tested as an antitumor prodrug that requires reduction to the 2… CONTINUE READING
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