Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.

@article{Luch1997MetabolicAO,
  title={Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.},
  author={Andreas Luch and Andreas Seidel and Hansruedi Glatt and Karl L. Platt},
  journal={Chemical research in toxicology},
  year={1997},
  volume={10 10},
  pages={
          1161-70
        }
}
  • Andreas Luch, Andreas Seidel, +1 author Karl L. Platt
  • Published in
    Chemical research in…
    1997
  • Chemistry, Medicine
  • Polycyclic aromatic hydrocarbons require metabolic activation in order to exert their biological activity initiated by DNA binding. The metabolic pathway leading to bay or fjord region dihydrodiol epoxides as ultimate mutagenic and/or carcinogenic metabolites is thought to play a dominant role. For dibenzo[a,l]pyrene, considered as the most potent carcinogenic polycyclic aromatic hydrocarbon, the formation of the fjord region syn- and/or anti-11,12-dihydrodiol 13,-14-epoxide (DB[a,l]PDE… CONTINUE READING

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