Metabolic activation of chlorinated ethylenes: dependence of mutagenic effect on electrophilic reactivity of the metabolically formed epoxides

@article{Henschler1977MetabolicAO,
  title={Metabolic activation of chlorinated ethylenes: dependence of mutagenic effect on electrophilic reactivity of the metabolically formed epoxides},
  author={Dietrich Henschler and Gerhard Bonse},
  journal={Archives of Toxicology},
  year={1977},
  volume={39},
  pages={7-12}
}
  • Dietrich Henschler, Gerhard Bonse
  • Published in Archives of Toxicology 1977
  • Chemistry, Medicine
  • In chlorinated ethylenes, the chlorine substitution exerts, by its electron withdrawal effect, a stabilization of the molecule which increases with the number auf chlorine residues. All chlorinated ethylenes are metabolically transformed, in a first step reaction, to epoxides which may rearrange to aldehydes or acyl chlorides, respectively, undergo hydrolysis to diols, conjugate with glutathione, or react, by alkylation, with cellular macromolecules. The electrophilicity of the epoxides is high… CONTINUE READING

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    Citations

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    • Egon Marth
    • Chemistry, Medicine
    • Archives of Toxicology
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    CITES BACKGROUND

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    • Fluate Densinfluat, Narcogen Germalgene, Threthylen Narkosoid, Trethylene Threthylene
    • 1978

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