Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

@article{Arlt2007MetabolicAO,
  title={Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.},
  author={Volker M Arlt and Marie Stiborov{\'a} and Colin J. Henderson and Markus Thiemann and Eva Dr. Frei and Dagmar Aimov{\'a} and Rajinder Pal Singh and Gonçalo Gamboa da Costa and Oliver J Schmitz and Peter B. Farmer and C. R. Wolf and David H Phillips},
  journal={Carcinogenesis},
  year={2007},
  volume={29 3},
  pages={
          656-65
        }
}
Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are metabolically activated by cytochrome P450s (CYPs). In order to evaluate the role of hepatic versus extra-hepatic metabolism of BaP and its pharmacokinetics, we used the hepatic cytochrome P450 reductase null (HRN) mouse model, in which cytochrome P450 oxidoreductase, the unique electron donor to CYPs, is deleted specifically in hepatocytes… CONTINUE READING

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