Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.

@article{Czerwinski1991MetabolicAO,
  title={Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.},
  author={Maciej Czerwinski and T L Mclemore and Richard M. Philpot and P T Nhamburo and Ken Korzekwa and H. V. Gelboin and Frank J. Gonzalez},
  journal={Cancer research},
  year={1991},
  volume={51 17},
  pages={4636-8}
}
4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by cytochromes P-450 (P-450s). P-450-mediated activation of 4-ipomeanol to DNA binding metabolites was evaluated using a vaccinia virus complementary DNA expression system and an in situ DNA-binding assay. Twelve human P-450s and two rodent P-450s were expressed in human hepatoma Hep G2 cells and examined for their abilities to metabolically activate this toxin. Three forms, designated CYP1A2, CYP3A3, and… CONTINUE READING
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