Metabolic activation and deactivation of mutagens by preparations of human lung parenchyma and bronchial tree.

69 S12 preparations of human lung (43 of peripheral lung parenchyma and 26 bronchial preparations) were assayed for their ability to activate procarcinogens to mutagenic metabolites in the Ames test or to lower the mutagenic response of direct-acting compounds. No sample activated polycyclic aromatic hydrocarbons, such as 3-methylcholanthrene, benzo[a… CONTINUE READING